Everything

Here’s an attack right out of the movie Scanners: With a combined – and extremely vulgar – assault of Life 3/ Mind 3 (or Mind 3/ Prime 2), the psychic assailant blasts her opponent with aggravated damage. Again, the difficulty is the target’s Willpower (or that Trait + 3/ + 5). In this case, however, the injuries tear straight into the Pattern of the target’s brain, inflicting an attack that cannot be soaked except perhaps by a Mind-Effect psychic shield or some other form of internal protection around the brain. (Armor or tough skin, after all, cannot protect you from the inside…)

Even if the target survives, she might have to make a Willpower roll or else suffer from Things Man Was Not Meant to Know. The difficulty, in this case, would be the number of health levels she suffered from the attack. And even if she does avoid its worst effects, the psychological scars from such attacks can last a lifetime.