Everything

You can drink folks under the table or otherwise party till everybody else drops. System-wise, this Merit lets you

make a Stamina roll (difficulty 7) to shake off the effects of intoxication – a useful talent for hard-pounding Ecstatics and tough-as-leather Black Suits!

In its one-point form, this Merit functions only for “natural” drugs (booze, pot, cocaine, etc.), not for lab-synthesized concoctions (LSD, meth, krokodil, etc.). For two points, however, the Merit can neutralize the psychoactive effects of any drug unless that drug has been created as the vector for a Sphere-based magickal Effect. (That is, say, a pill that delivers a Life 3 /Mind 3 Effect to the person who takes it, as opposed to an “ordinary” pill that a mage takes as part of the focus instruments Drugs and Poisons or Brews, Potions, and so forth, as detailed in Mage 20, pp. 588-600.) In the latter case, the character needs to use countermagick; this Merit will not help to counteract such drugs. “Awakened” substances, however (as per Mage 20, p. 443) are treated as “synthesized concoctions” even if they are, in all other forms, “natural.

For a more comprehensive resistance to toxins, see Poison Resistance, below.